F Worek Selected Research

Oximes

1/2020	A case report of cholinesterase inhibitor poisoning: cholinesterase activities and analytical methods for diagnosis and clinical decision making.
12/2013	Investigations of kinetic interactions between lipid emulsions, hydroxyethyl starch or dextran and organophosphorus compounds.
4/2012	Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro.
3/2012	Competition radioligand binding assays for the investigation of bispyridinium compound affinities to the human muscarinic acetylcholine receptor subtype 5 (hM(5) ).
9/2011	Immobilization of Russian VX skin depots by localized cooling: implications for decontamination and medical countermeasures.
9/2011	In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species.
9/2011	Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6.
9/2011	Interaction of bispyridinium compounds with the orthosteric binding site of human α7 and Torpedo californica nicotinic acetylcholine receptors (nAChRs).
7/2011	The therapeutic use of localized cooling in the treatment of VX poisoning.
5/2011	Pre- and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro.

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F Worek Research Topics

Disease

31	Poisoning 01/2020 - 01/2000
3	Respiratory Insufficiency (Respiratory Failure) 11/2009 - 08/2006
2	Organophosphate Poisoning 12/2013 - 05/2009
2	Disease Progression 11/2009 - 04/2007
1	Cardiac Arrhythmias (Arrythmia) 10/2021
1	Miosis 07/2011
1	Necrosis 07/2008
1	Wounds and Injuries (Trauma) 06/2007
1	Erythema 05/2007
1	Diarrhea 01/2000
1	Vomiting 01/2000
1	Dizziness (Lightheadedness) 01/2000
1	Muscle Cramp (Cramp) 01/2000

Drug/Important Bio-Agent (IBA)

22	OximesIBA 01/2020 - 03/2000
13	Nerve AgentsIBA 12/2013 - 03/2007
9	Atropine FDA LinkGeneric 04/2012 - 01/2000
5	Organophosphorus CompoundsIBA 12/2013 - 04/2007
5	Muscarinic AntagonistsIBA 06/2013 - 09/2002
5	Obidoxime Chloride (Obidoxime)IBA 09/2011 - 04/2007
4	Cholinergic Agents (Cholinergics)IBA 01/2020 - 08/2006
4	asoxime chloride (H16)IBA 09/2011 - 07/2006
4	pralidoxime (Protopam Chloride)FDA Link 09/2011 - 06/2007
4	AcetylcholinesteraseIBA 05/2011 - 04/2007
4	PesticidesIBA 11/2009 - 08/2006
3	Cholinesterases (Cholinesterase)IBA 01/2020 - 07/2011
3	MB327IBA 09/2018 - 04/2012
3	Therapeutic UsesIBA 06/2013 - 05/2011
3	SomanIBA 09/2011 - 04/2007
3	VX (EDIM)IBA 07/2011 - 07/2006
3	InsecticidesIBA 11/2009 - 03/2000
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2020 - 01/2000
2	ButyrylcholinesteraseIBA 05/2009 - 06/2008
2	SarinIBA 06/2007 - 04/2007
2	Chemical Warfare AgentsIBA 05/2007 - 04/2007
2	OrganophosphatesIBA 09/2002 - 03/2000
1	GlycosidesIBA 10/2021
1	Adenosine Triphosphatases (ATPase)IBA 10/2021
1	cannogenin thevetoside (peruvoside)IBA 10/2021
1	oleandrinIBA 10/2021
1	DigitoxigeninIBA 10/2021
1	Digoxin (Digitek)FDA LinkGeneric 10/2021
1	neriifolinIBA 10/2021
1	thevetineIBA 10/2021
1	AntidotesIBA 01/2020
1	Pharmaceutical PreparationsIBA 01/2020
1	LigandsIBA 04/2016
1	LipidsIBA 12/2013
1	Dextrans (Dextran)FDA Link 12/2013
1	EmulsionsIBA 12/2013
1	Starch (Cornstarch)IBA 12/2013
1	Drug CombinationsIBA 04/2012
1	CarbamatesIBA 09/2011
1	PoisonsIBA 07/2011
1	PhysostigmineIBA 05/2011
1	BuffersIBA 03/2011
1	Phosphates (Orthophosphate)IBA 03/2011
1	profenofosIBA 11/2009
1	prothiophosIBA 11/2009
1	Adenosine Triphosphate (ATP)IBA 07/2008
1	Chlorpyrifos (Lorsban)IBA 06/2008
1	Dimethoate (Rogor)IBA 06/2008
1	Biological ProductsIBA 06/2007
1	CausticsIBA 06/2007
1	Mustard Gas (Sulfur Mustard)IBA 05/2007
1	Alkylating AgentsIBA 05/2007
1	phosphoryl oxime hydrolaseIBA 03/2000
1	TeaIBA 01/2000
1	huperzine AIBA 01/2000

Therapy/Procedure

6	Therapeutics 01/2020 - 01/2000